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Epidemiology Publications on Acrylonitrile

  1. Benn, T. and Osborne, K. (1998). Mortality of United Kingdom Acrylonitrile Workers: An Extended and Updated Study. Scand J Work Environ Health, 24 (Suppl 2), 71-80.

  2. Blair, A. and Kazerouni, N. (1997). Reactive Chemicals and Cancer. Cancer Causes and Control, 8, 473-90.

  3. Blair, A., Stewart, P.A., Zaebst, D., Pottern, L., Zey, J., Bloom, T., Miller, B., Ward, E. and Lubin, J. (1998). Mortality Study of Industrial Workers Exposed to Acrylonitrile. Scand J Work Environ Health, 24 (Suppl 2), 25-41.

  4. Coggon, D. and Cole, P. (1998). Acrylonitrile and Human Cancer-An Overview. Scand J Work Environ Health, 24 (Suppl 2), 81-2.

  5. Collins, J.J. and Acquavella, J.F. (1998). Review and Meta-Analysis of Studies of Acrylonitrile Workers. Scand J Work Environ Health, 24, 71-80.

  6. Collins, J.J. and Strother, D. (1999). Central Nervous System Tumors and Exposure to Acrylonitrile: Inconsistency Between the Experimental and Epidemiology Studies. Neuro-Oncology, 1, 221-30, (Posted to Neuro-Oncology [serial online], Doc. 99-10, June 9,1999. URL neuro-oncology.mc.duke.edu).

  7. Czeizel, A.E., Szilvasi, R., Timar, L. and Puho, E. (2004). Occupational Epidemiological Study of Workers in an Acrylonitrile Using Factory with Particular Attention to Cancers and Birth Defects. Mutation Research, 547, 79-89.

  8. Doll, R. (1998). Preface. Scand J Work Environ Health, 24 (Suppl 2), 3-4.

  9. Marsh, G.M., Youk, A.O. and Collins, J.J. (2001). Reevaluation of Lung Cancer Risk in the Acrylonitrile Cohort Study of the National Cancer Institute and the National Institute for Occupational Safety and Health. Scand J Work Environ Health, 27 (1), 5-13.

  10. Starr, T.B., Gause, C., Youk, A.O., Stone, R., Marsh, G.M. and Collins, J.J. (2004). A Risk Assessment for Occupational Acrylonitrile Exposure Using Epidemiology Data. Risk Analysis, 24 (3), 587-601.

  11. Strother, D.E., Mast, R.W., Kraska, R.C. and Frankos, V. (1988). Acrylonitrile as a Carcinogen: Research Needs for Better Risk Assessment. Annals of the NY Academy of Sciences, 534, 169-78.

  12. Swaen, G.M., Bloemen, L.J., Twisk, J., Scheffers, T., Slangen, J.J., Collins, J.J., ten Berge, W.F. and Sturumans, F. (1998). Mortality Update of Workers Exposed to Acrylonitrile in the Netherlands. Scand J Work Environ Health, 24 (Suppl 2), 10-16.

  13. Ward, C.E. and Starr, T.B. (1993). Comparison of Cancer Risks Projected from Animal Bioassays to Epidemiologic Studies of Acrylonitrile-Exposed Workers. Reg Tox Pharm, 18, 214-32.

  14. Wood, S.M., Buffler, P.A., Burau, K. and Krivanek, N. (1998). Cohort Study of DuPont Employees Exposed to Acrylonitrile. Scand J Work Environ Health, 24 (Suppl 2), 54-62.

Toxicology Publications on Acrylonitrile

  1. Campian, E.C., Cai, J. and Benz, F.W. (2002). Acrylonitrile Irreversibly Inactivates Glyceraldehyde-3-Phosphate Inactivates Alkylating the Catalytically Active Cysteine 149. Chemico-Biological Interaction, 140, 279-91.

  2. Fechter, L.D., Gearhart, C. and Shirwany, N.A. (2004). Acrylonitrile Potentiates Noise-Induced Hearing Loss in Rat. JARO, 5 (1), 90-8.

  3. Felter, S.P. and Dollarhide, J.S. (1997). Acrylonitrile: A Reevaluation of the Database to Support an Inhalation Cancer Risk Assessment. Reg Tox Pharm, 26, 281-7.

  4. Friedman, M.A. and Beliles, R.P. (2002). Three-Generation Reproduction Study of Rats Receiving Acrylonitrile in Drinking Water. Toxicology Letters, 132, 249-61.

  5. Jiang, J., Xu, Y. and Klaunig, J.E. (1998). Induction of Oxidative Stress in Rat Brain by Acrylonitrile. Tox Sciences, 46 (2), 333-41.

  6. Johannsen, F.R. and Levinskas, G.J. (2002). Chronic Toxicity and Oncogenic Dose-Response Effects of Lifetime Oral Acrylonitrile Exposure to Fischer 344 Rats. Toxicology Letters, 132 (3), 221-47.

  7. Johannsen, F.R. and Levinskas, G.J. (2002). Comparative Chronic Toxicity and Carcinogenicity of Acrylonitrile by Drinking Water and Oral Intubation to Spartan (R) Sprague-Dawley Rats. Toxicology Letters, 132 (3), 197-219.

  8. Kamendulis, L.M., Jiang, J., Xu, Y. and Klaunig, J.E. (1999). Induction of Oxidative Stress and Oxidative Damage in Rat Glial Cells by Acrylonitrile. Carcinogenesis, 20 (8), 1555-60.

  9. Kamendulis, L.M., Jiang, J., Zhang, H., deFeijter-Rupp, H., Trosko, J.E. and Klaunig, J.E. (1999). The Effect of Acrylonitrile on Gap Junction Intercellular Communication in Rat Astrocytes. Cell Bio Tox, 15, 173-83.

  10. Kedderis, G.L. and Batra, R. (1993). Species Differences in the Hydrolysis of 2-Cyanoethylene Oxide, the Epoxide Metabolite of Acrylonitrile. Carcinogenesis, 14, 685-9.

  11. Kedderis, G.L., Teo, S.K., Batra, R., Held, S.D. and Gargas, M.L. (1996). Refinement and Verification of the Physiologically Based Dosimetry Description for Acrylonitrile in Rats. Tox App Pharm, 140, 422-35.

  12. Kirman, C.R., Hays, S.M., Kedderis, G.L., Gargas, M.L. and Strother, D.E. (2000). Improving Cancer Dose-Response Characterization Using Physiologically Based Pharmacokinetic Modeling: An Analysis of Pooled Data for Acrylonitrile-Induced Brain Tumors to Assess Cancer Potency in the Rat. Risk Analysis, 20, 135-51.

  13. Osterman-Golkar, S.M., MacNeela, J.P., Turner, M.J., Walker, V.E., Swenberg, J.A., Sumner, S.J., Youtsey, N. and Fennell, T.R. (1994). Monitoring Exposure to Acrylonitrile Using Adducts with N-terminal Valine in Hemoglobin. Carcinogenesis, 15 (12), 2701-7.

  14. Quast, J.F. (2002). Two-Year Toxicity and Oncogenicity Study With Acrylonitrile Incorporated in the Drinking Water of Rats. Toxicology Letters, 132, (3), 153-96.

  15. Schettgen, T., Broding, H.C., Angerer, J. and Drexler, H. (2002). Hemoglobin Adducts of Ethylene Oxide, Propylene Oxide, Acrylonitrile and Acrylamide-Biomarkers in Occupational and Environmental Medicine. Toxicology Letters, 134, 65-70.

  16. Sweeney, L.M., Gargas, M.L., Strother, D.E. and Kedderis, G.K. (2002). Physiologically Based Pharmacokinetic Model Parameter Estimation and Sensitivity and Variability Analyses for Acrylonitrile Disposition in Humans. Tox Sciences, 71, 27-40.

  17. Whysner, J., Ross, P.M., Conaway, C.C., Verna, L.K. and Williams, G.M. (1998). Evaluation of Possible Genotoxic Mechanisms for Acrylonitrile Tumorigenicity. Reg Tox Pharm, 27 (3), 217-39.

  18. Whysner, J., Steward, R.E., Chen, D., Conaway, C.C., Verna, L.K., Richie, J.P., Ali, N. and Williams, G.M. (1998). Formation of 8-oxodeoxyguanosine in Brain DNA of Rats Exposed to Acrylonitrile. Arch Tox, 72 (7), 429-38.

  19. Xu, D.X., Zhu, Q.X., Zheng, L.K., Wang, Q.N., Shen, H.M., Deng, L.X. and Ong, C.N. (2003). Exposure to Acrylonitrile Induced DNA Strand Breakage and Sex Chromosome Aneuploidy in Human Spermatozoa. Mutation Research, 537 (1), 93-100.

  20. Zhang, H., Xu, Y., Kamendulis, L.M. and Klaunig, J.E. (2000). Morphological Transformation by 8-Hydroxy-2'-deoxyguanosine in Syrian Hamster Embryo Cells. Tox Sciences, 56, 303-12.

  21. (1999). IARC Monographs on the Evaluation of Carcinogenic Risks in Humans: Acrylonitrile, 71 (Part 1), 43-108.


Last Updated - July 14, 2004


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